About NASH
NASH is an emerging world crisis that affects some 3-5% of the US population, and 2-4% of the glob al population.
It is the fastest growing cause of liver cancer and liver transplant in the US, especially due to the rise in obesity.
NASH in Numbers
#1
Cause for chronic
liver disease
worldwide
2nd
Leading cause for
liver transplant
in the U.S.
37%
of diabetic
patients
have NASH
17%
of diabetic
patients suffer
from advanced
fibrosis
20%
of advanced
fibrosis becomes
life threating
within 2 years
NASH FAQ
What is NASH?
>
NASH (Nonalcoholic Steatohepatitis) is liver inflammation and damage caused by a buildup of fat in the liver.
In some people, the fat causes inflammation and damages cells in the liver.
Because of the damage, the liver does not function as well as it should.
NASH can get worse and cause liver scarring (fibrosis), which can progress to severe scarring (cirrhosis) and lead to life-threatening complications, including liver failure and liver cancer.
HEALTHY LIVER
STEATOSIS
NASH
CIRRHOSIS
OUTCOMES
What are the symptoms of NASH?
>
Usually, NASH is a silent disease with few or no symptoms. Most people who have NASH feel fine and don’t know that they have it. You may not have symptoms even if you develop cirrhosis due to NASH.
If you do have symptoms, you may feel tired or have discomfort in the upper right side of your belly.
It can take many years for NASH to become severe enough to cause symptoms.
Who’s at risk for NASH?
>
Diabetes
NASH is more
common in patients
with pre-diabetes or
type 2 diabetes
weight
NASH is closely associated with being overweight or obese
high blood pressure
People with high blood pressure are at increased risk for NASH
high cholesterol
High cholesterol is a condition associated with NASH
ethnic background
NASH is more commonly seen in Hispanics than other ethnic groups
age
NASH is most often
found in people between the ages of 40 & 60
How is NASH diagnosed?
>
No single test can diagnose NASH. To see if fat is building up in your liver, rule out other diseases and diagnose NASH, your doctor may use your medical history, a physical exam, and various tests. These tests may include blood tests, imaging tests, and sometimes a liver biopsy. In a liver biopsy, your doctor takes a sample of tissue from your liver and checks it for signs of NASH. Currently, liver biopsy is the most accurate way to diagnose NASH.
How is NASH treated?
>
Currently, there are no medications approved for the treatment of NASH. You may be able to prevent NASH and slow it’s progression by making healthy food choices, being physically active, stopping or cutting back on drinking alcohol, and maintaining a healthy weight. Doctors recommend gradually losing 3 to 5% of your body weight to reduce fat in the liver and losing up to 10% of your body weight to reduce liver inflammation.
What can I do?
>
Join the ARMOR study! ARMOR is a new clinical trial testing Aramchol™ – an investigational treatment for patients with NASH. Aramchol™ aims to slow down or stop NASH from progressing to cirrhosis and liver failure. Aramchol™ has been studied extensively and in a recent study of 247 NASH patients like you, Aramchol™ showed potentially beneficial effects, along with excellent safety.
Additional Resources on Liver Disease
Contat Us
For patients:
armorinfo@galmedpharma.com
For Medical & Healthcare providers:
clinicaltrial@galmedpharma.com